It was a good assumption. These days most games will work flawlessly in WINE/Proton, but the same can’t be said for other Windows software, sadly.

The Affinity suite is notoriously difficult to get working properly in WINE and/or Proton

I currently run it in a Windows 10 VM using virt-manager and the virtio drivers from RedHat to enable OpenGL acceleration on a Windows guest. It is a decent experience. Would probably be much better if I passed a USB pointer directly into the VM instead of relying on virtualization.

Haven’t tried it in WINE, and probably will never bother until the Affinity team take it seriously.

Can’t speak to your other software, but battle.net and diablo 2 run great on Linux via WINE/Proton